Effects of Ginger (Zingiber officinale) as a Dietary Supplement on the Physiology and Health of Poultry
Main Article Content
Abstract
The increasing incorporation of antibiotics into poultry feed for growth development and disease prevention has resulted in serious health implications and the emergence of antimicrobial-resistant bacterial strains. The present study aimed to investigate the effects of ginger (Zingiber officinale) powder, as a dietary supplement, on immune response, gut integrity, total antioxidant capacity, and hematological and biochemical parameters in different poultry breeds. The present review examined 76 studies on the effects of dietary ginger on the health and physiology of poultry, including broiler and layer chickens, quail, and turkeys. Only peer-reviewed, indexed, full-text articles published in English were considered and investigated. Natural alternatives, such as ginger powder and its derivatives, in poultry production systems have been shown to mitigate antibiotic-related challenges and have been widely incorporated into poultry feed mixtures. Ginger supplementation in the feed of laying hens, broiler chickens, broiler chicks, and quail has enhanced intestinal integrity and increased the immune response against several viral diseases affecting poultry, such as Newcastle disease, infectious bursal disease, and avian influenza. Ginger has reduced glucose, triglycerides, and total cholesterol levels and increased high-density lipoprotein levels, thereby improving hematological parameters such as red blood cell count, hemoglobin, and packed cell volume, as well as kidney and liver functions. Ginger reduced oxidative stress and improved antioxidant status. Dietary ginger supplementation in poultry diets could serve as a natural feed additive to enhance growth, immunity, and overall health across poultry species, although optimal dosage may differ by species, age, and health status.
Article Details

This work is licensed under a Creative Commons Attribution 4.0 International License.
References
Halder N, Sunder J, De AK, Bhattacharya D, and Joardar SN. Probiotics in poultry: A comprehensive review. J Basic Appl Zool. 2024; 85(1): 23. DOI: 10.1186/s41936-024-00379-5
Urban J, Kareem K, Matuszewski A, Bien D, Ciborowska P, Lutostanski K, et al. Enhancing broiler chicken health and performance: The impact of photobiotic on growth, gut microbiota, antioxidants, and immunity. Phytochem Rev. 2025; 24: 2131-2145. DOI: 10.1007/s11101-024-09994-0
Lai W, Yang S, Lin X, Zhang X, Huang Y, Zhou J, et al. Zingiber officinale: A systematic review of botany, phytochemistry and pharmacology of gut microbiota-related gastrointestinal benefits. Am J Chin Med. 2022; 50(4): 1007-1042. DOI: 10.1142/S0192415X22500410
Deng M, Yun X, Ren S, Qing Z, and Luo F. Plants of the genus Zingiber: A review of their ethnomedicine, phytochemistry and pharmacology. Molecules. 2022; 27(9): 1-25. DOI: 10.3390/molecules27092826
Srinivasan K. Ginger rhizomes (Zingiber officinale): A spice with multiple health beneficial potentials. Pharma Nutrition. 2017; 5(1): 18-28. DOI: 10.1016/j.phanu.2017.01.001
Shirooye P, Mokaberinejad R, Ara L, and Moghadam MH. Volatile constituents of ginger oil prepared according to Iranian traditional medicine and conventional method: A comparative study. Afr J Tradit Complement Altern Med. 2016; 13(6): 68-73. DOI: 10.21010/ajtcam.v13i6.11
Mohamed AB, Al-Rubaee MAM, and Jalil AQ. Effect of ginger (Zingiber officinale) on performance and blood serum parameters of broiler. 2012; 11(2): 143-146. DOI: 10.3923/ijps.2012.143.146
Qorbanpour M, Fahim T, Javandel F, Nosrati M, Paz E, Seidavi A, et al. Effect of dietary (Zingiber officinale) and multi-strain probiotic on growth and carcass traits, blood biochemistry, immune responses and intestinal microflora in broiler chickens. Animals. 2018; 8(7): 117. DOI: 10.3390/ani8070117
Tasya SA, Nurgiartiningsih VMA, Permata FS, Djati MS, Nuningtyas YF, Hamiyanti AA, et al. Effects of ginger, turmeric, teak leaf extracts combined with a probiotic on broiler chicken performance. World Vet J. 2025; 15(3): 749-755. DOI: 10.54203/scil.2025.wvj76
Kairalla MA, Aburas AA, and Alshelmani MF. Effect of diet supplemented with graded levels of ginger (Zingiber officinale) powder on growth performance, hematological parameters, and serum lipids of broiler chickens. Arch Razi Inst. 2022; 77(6): 2089-2095. DOI: 10.22092/ARI.2022.359958.2524
Hussein VA, and Abdulwahid MT. Impact of dietary ginger and ginseng powder in broiler diet on the physiological traits and immune response of avian influenza. Indian J Forensic Med Toxicol. 2022; 16(2): 425-432. DOI: 10.37506/ijfmt.v16i2.18014
Bayril T, Akdemir F, Gürgöze S, and Orhan C. Effect of dietary stevia and ginger extracts on laying performance, fertility, hatchability, and serum biochemical parameters in laying Japanese quails exposed to heat stress. J Anim Feed Sci. 2023; 32(3): 289-296. DOI: 10.22358/jafs/160328/2023
Ibtisham F, Nawab A, Niu Y, Wang Z, Wu J, Xiao M, et al. The effect of ginger powder and Chinese herbal medicine on production performance, serum metabolites and antioxidant status of laying hens under heat-stress condition. J Therm Biol. 2019; 81: 20-24. DOI: 10.1016/j.jtherbio.2019.02.002
Bouchama C, Yousfi L, El Akhdari S, Chadli N, Samouh K, Raoui S, et al. Effect of feed supplementation with Curcuma longa and Zingiber officinale spices on the zootechnical, biochemical, and microbiological parameters of broiler chickens. Not Sci Biol. 2024; 16(3): 11948. DOI: 10.15835/nsb16311948
Abdulhamid ABA, Alraeboub BM, Mohamed RD, and Qareerah AS. Impact of ginger and propolis-enriched diets on the immune system of Japanese quails: An in-depth analysis. Afro-Asian J Sci Res. 2023; 1(4): 241-253. Available at: https://search.emarefa.net/en/detail/BIM-1684389-impact-of-ginger-and-propolis-enriched-diets-on-the-immune-s
Al-Hadad MA, Al-Samarrai RR, and Ahumaih MJ. Phytochemical constituents and nutrient evaluation of Zingiber officinale. Tikrit J Pure Sci. 2023; 22(3): 89-96. DOI: 10.25130/tjps.v22i3.717
Azadmanesh R, Gholami-Ahangaran M, Karimi-Dehkordi M, and Fathi Hafsanjani E. The immunomodulatory effects of ginger extract on hematological indices and humoral immune response in ostriches vaccinated against Newcastle disease. Vet Comp Biomed Res. 2024; 1(2): 72-76. DOI: 10.22103/vcbr.2024.23657.1022
Saber A, Mawas AS, Khalil AM, Ahmed AI, Shibat Elhamd DM, Ali E, et al. Therapeutic impact of dietary ginger supplementation in chickens experimentally infected with coccidia: Antioxidant, biochemical, and pathological evaluations. Front Vet Sci. 2025; 12: 1511759. DOI: 10.3389/fvets.2025.1511759
Rehman ZU, Chand N, and Khan RU. The effect of vitamin E, L-carnitine, and ginger on production traits, immune response, and antioxidant status in two broiler strains exposed to chronic heat stress. Environ Sci Pollut Res. 2017; 24(34): 26851-26858. DOI: 10.1007/s11356-017-0304-8
Hecrudeati H, Anisa AK, Widiatmoko KD, Alam SSP, Diari IA, Naprila ZH, et al. Effect of red ginger powder (Zingiber officinale var. rubrum) as a feed additive for starter and finisher broiler chicken to increase immunoglobulin A and immunoglobulin Y expression and to prevent intestinal injury due to Salmonella enteritidis infection. Vet World. 2022; 15(6): 1506-1514. DOI: 10.14202/vetworld.2022.1506-1514
El-kashef MMA. Evaluation of using ginger (Zingiber officinale) on growth performance, carcass characteristics, blood biochemistry and immune responses of quail birds. Egypt Poult Sci J. 2022; 42(2): 199-212. DOI: 10.21608/epsj.2022.249546
Asghar MU, Rahman A, Hayat Z, Rafique MK, Badar IH, Yar MK, et al. Exploration of Zingiber officinale effects on growth performance, immunity and gut morphology in broilers. Braz J Biol. 2023; 83: e250296. DOI: 10.1590/1519-6984.250296
Raziq F, Mushtaq M, Bughio E, Khan MT, Hameed A, Bachaya HA, et al. Dose dependence studies of aniseed (Pimpinella anisum) and ginger (Zingiber officinale) extract mixture on growth promoting and immunomodulatory effects in broiler chicks. Pure Appl Biol. 2023; 12(1): 197-205. DOI: 10.19045/bspab.2023.120021
Alharbi A, Fekry NM, Osailan R, Bahshwan SMA, Al-Ghamdi FA, Al Ghamdi M, et al. Combinatorial effects of ginger and garlic essential oils on broiler chicken performance, digestive functions, immunity, organ function, oxidative stress and defense genes under heat stress. Pak Vet J. 2025; 45(4): 1806-1816. DOI: 10.29261/pakvetj/2025.337
Tong Y, Wang Y, Zhang J, Guo Y, Yuan T, Chen H, et al. Narrative study on the impact of ginger extract on laying performance, egg quality, inflammatory responses, intestinal barrier function, and cecal microbiome and resistance in laying hens. Poult Sci. 2025; 104(10): 105448. DOI: 10.1016/j.psj.2025.105448
Ayustaningwarno F, Anjani G, Ayu AM, and Fogliano V. A critical review of ginger's (Zingiber officinale) antioxidant, anti-inflammatory, and immunomodulatory activities. Front Nutr. 2024; 11: 1364836. DOI: 10.3389/fnut.2024.1364836
Valdez G, Shyur L, Wang SY, and Chen SE. Phytogenics in ginger, Origanum vulgare, and Syzygium aromaticum and their potential as a feed additive against Clostridium perfringens in broiler production. Animals. 2023; 13(23): 3643. DOI: 10.3390/ani13233643
Nawal KS, Mahbuba AGM, and Nidhal AGM. Impact of ginger powder supplementation in broiler diet on the immune status development and small intestine morphology. Basra J Vet Res. 2018; 17(2): 99-112. Available at: https://bjvr.uobasrah.edu.iq/article_160400_515eea4d4e45e44b2821d8daa923f54e.pdf
Zhang M, Viennois E, Prasad M, Zhang Y, Wang L, Zhang Z, et al. Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer. Biomaterials. 2016; 101: 321-340. DOI: 10.1016/j.biomaterials.2016.06.018
Hassan A, Youssef I, Abdel-Atty N, and Abdel-Daim A. Effect of thyme, ginger, and their nano-particles on growth performance, carcass characteristics, meat quality and intestinal bacteriology of broiler chickens. BMC Vet Res. 2024; 20(1): 269. DOI: 10.1186/s12917-024-04101-z
Hassan R, Mosaad GM, and Abd El-wahab HY. Effect of dietary supplemental ginger on broiler performance, carcass characteristics and blood profile. Int J Vet Sci. 2019; 2(1): 108-118. DOI: 10.21608/svu.2019.6404.1000
Ajao AM, Oso AO, Lala AO, Olowofeso O, and Adeniran AD. Effect of varying level of ginger powder in the diet of starter turkeys on performance, haematological and serum biochemical indices. Niger J Anim Prod. 2018; 45(1): 212-223. DOI: 10.51791/njap.v45i1.330
Al-Khalaifah H, Al-Nasser A, Al-Surrayai T, Sultan H, Al-Attal D, Al-Kandari R, et al. Effect of ginger powder on production performance, antioxidant status, hematological parameters, digestibility, and plasma cholesterol content in broiler chickens. Animals. 2022; 12(7): 901. DOI: 10.3390/ani12070901
Qorbani M, Fahim T, Javandel F, Nosrati M, Paz E, Seidavi A, et al. Effect of dietary ginger (Zingiber officinale Roscoe) and multi-strain probiotic on growth and carcass traits, blood biochemistry, immune responses and intestinal microflora in broiler chickens. Animals. 2018; 8(7): 114. DOI: 10.3390/ani8070114
Okusanya PO, Akinlade OO, Jarikre TA, and Okiya MA. Growth performance, gut histology and anti-coccidial effect of aqueous blends of scent leaf, ginger and garlic in broiler chicken. Niger Vet J. 2023; 44(4): 1-10. DOI: 10.4314/nvj.v44i4.2
Sultan A, Aziz T, Islam Z, Uzair MS, Alhindary IA, Khan RU, et al. Effect of ginger-based zingibain enzyme on growth and intestinal health in Japanese quails. Arch Anim Breed. 2024; 67(4): 571-581. DOI: 10.5194/aab-67-571-2024
Jin S, Shi J, Zhao M, Liu X, Yang K, Shang E, et al. The influence of dietary supplementation with ginger ethanol extract on laying hens' production performance, antioxidant capacity, and gut microbiota. Front Vet Sci. 2025; 12: 1652982. DOI: 10.3389/fvets.2025.1652982
Jaric MD, Gottstein Z, Vince S, Zaja IZ, Brus M, Duricic D, et al. Effect of standardized ginger (Zingiber officinale Roscoe) extract on gut morphology, microbiota composition, and growth performance in broiler chickens. Agriculture. 2025; 15(13): 1448. DOI: 10.3390/agriculture15131448
Ahmad U, Sultan A, Khan S, and Tahir M. Effect of ginger derived phyto-protease on production performance, serum biochemistry, nutrient digestibility, gut morphometry and immunity of broilers fed high level of poultry by-product meal-based diet. Pak J Zool. 2024; 56(3): 1233-1242. DOI: 10.17582/journal.pjz/20221031071042
Karangiya VK, Savsani HH, Patil SS, Garg DD, Murthy KS, Ribadiya NK, et al. Effect of dietary supplementation of garlic, ginger, and their combination on feed intake, growth performance, and economics in commercial broilers. Vet World. 2016; 9(3): 245-250. DOI: 10.14202/vetworld.2016.245-250
Shewita R, and Taha A. Influence of dietary supplementation of ginger powder at different levels on growth performance, haematological profiles, slaughter traits and gut morphometry of broiler chickens. S Afr J Anim Sci. 2018; 48(6): 997-1008. DOI: 10.4314/sajas.v48i6.1
Liu J, Jin Y, and Yang J. Influence of spent ginger yeast cultures on the production performance, egg quality, serum composition, and intestinal microbiota of laying hens. Anim Biosci. 2022; 35(8): 1205-1214. DOI: 10.5713/ab.21.0514
Ali S, Sultan A, Islam Z, Uzair M, Almutairi M, Alrefaei A, et al. Influence of different levels of ginger-derived liquid protease on growth performance, nutrient digestibility, immune organs and gut pH in broiler chickens. J Anim Physiol Anim Nutr. 2025; 109(5): 1174-1181. DOI: 10.1111/jpn.14129
Khan A, Sultan A, Islam Z, Uzair M, Alhidary I, Khan R, et al. Optimising growth performance, nutrients digestibility, immunity and gut health in broilers through ginger-derived phyto-protease enzyme (zingibain) supplementation. Ital J Anim Sci. 2024; 23(1): 1695-1703. DOI: 10.1080/1828051X.2024.2416586
Zhang JC, Chen P, Zhang C, Khalil MM, Zhang NY, Qi DS, et al. Yeast culture promotes the production of aged laying hens by improving intestinal digestive enzyme activities and the intestinal health status. Poult Sci. 2020; 99(4): 2026-2032. DOI: 10.1016/j.psj.2019.11.017
Abd El-Hack M, Abo ElMaati M, Abusudah W, Awlya O, Almohmadi N, Fouad W, et al. Consequences of dietary cinnamon and ginger oils supplementation on blood biochemical parameters, oxidative status, and tissue histomorphology of growing Japanese quails. Poult Sci. 2024; 103(2): 103314. DOI: 10.1016/j.psj.2023.103314
Meligy AM, Abd El-Hamid MI, Yonis AE, Elhaddad GY, Abdel-Raheem SM, El-Ghareeb WR, et al. Liposomal encapsulated oregano, cinnamon, and clove oils enhanced the performance, bacterial metabolites antioxidant potential, and intestinal microbiota of broiler chickens. Poult Sci. 2023; 102(6): 102683. DOI: 10.1016/j.psj.2023.102683
Sahoo N, Mishra S, Swain R, Acharya A, Pattnaik S, Sethy K, et al. Effect of turmeric and ginger supplementation on immunity, antioxidant, liver enzyme activity, gut bacterial load and histopathology of broilers. Indian J Anim Sci. 2019; 89: 774-779. DOI: 10.56093/ijans.v89i7.92046
Zidan DE, Kahilo KA, El-Far AH, and Sadek KM. Effects of dietary supplementation of ginger (Zingiber officinale) and thymol on the performance, antioxidant status and immune response in broilers. Glob Vet. 2016; 16(6): 530-538. DOI: 10.5829/idosi.gv.2016.16.06.10442
Abdul-Majeed AF, Abdul-Rahman SY, and Al-krad HA. Effect of ginger on oxidative stress induced by hydrogen peroxide in male quail. Proceedings of 2nd International Multi-Disciplinary Conference Theme: Integrated Sciences and Technologies, IMDC-IST. Sakarya, Turkey. 2021. DOI: 10.4108/eai.7-9-2021.2315485
Nemati Z, Dehgani P, Karimi A, Amirdahri S, and Kianifard D. Effects of ginger (Zingiber officinale) supplementation on testicular histology, semen characteristic, blood plasma parameters and reproductive performance in aged broiler breeder roosters. J Anim Physiol Anim Nutr. 2022; 107(9): 1-13. DOI: 10.1111/jpn.13779
Derese D, Sun H, Xiong X, Li Z, Malyar R, Lu L, et al. Effects of dietary ginger (Zingiber officinale) rhizome powder supplementation on productive performance, egg quality, antioxidant capacity, and hepato-intestinal morphology in pre-peak Xiaoshan laying hens. Animals. 2025; 15(15): 2315. DOI: 10.3390/ani15152315
Abubakar JO, Uchechi NC, Abosede OO, and Samuel TO. Role of real phytogenic supplementation to protect cardiac, hepatic, nephrotic, and splenic oxidative stress in broiler chickens. Transl Anim Sci. 2023; 7(1): 1-8. DOI: 10.1093/tas/txad106
Apalowo OO, Minor RC, Adetunji AO, Ekunseitan DA, and Fasina YO. Effect of ginger root extract on intestinal oxidative status and mucosal morphometric in broiler chickens. Animals. 2024; 14(7): 1084. DOI: 10.3390/ani14071084
Surai PF, Kochish II, and Fisinin VI. Glutathione peroxidases in poultry biology: Part 1. Classification and mechanisms of action. World’s Poult Sci J. 2018; 74(2): 185-198. DOI: 10.1017/S0043933918000284
Jimoh OA, Ayodele AD, Ojo OA, Okin-Aminu HO, and Olarotimi OJ. Effects of turmeric, ginger, cinnamon, and garlic essential oils on HSP70, NFKB, oxidative DNA damage, inflammatory cytokines, and oxidative markers in broiler chickens. Transl Anim Sci. 2024; 8: txae127. DOI: 10.1093/tas/txae127
Ogbuewu IP, Mbajiorgu CA, and Okoli IC. Antioxidant activity of ginger and its effect on blood chemistry and production physiology of poultry. Comp Clin Pathol. 2019; 28(3): 655-660. DOI: 10.1007/s00580-017-2536-x
Reda FM, Alagawany M, Mahmoud HK, Mahgoub SA, and Elnesr SS. Use of red pepper oil in quail diets and its effect on performance, carcass measurements, intestinal microbiota, antioxidant indices, immunity and blood constituents. Animal. 2020; 14(5): 1025-1033. DOI: 10.1017/S1751731119002891
Wen C, Gu Y, Tao Z, Cheng Z, Wang T, and Zhou Y. Effects of ginger extract on laying performance, egg quality, and antioxidant status of laying hens. Animals. 2019; 9(11): 857. DOI: 10.3390/ani9110857
Aikpitanyi KU, and Egweh NO. Haematological and biochemical profile of broiler chickens fed diets containing ginger and black pepper additives. Niger J Anim Sci. 2020; 22(2): 114-125. Available at: https://njas.org.ng/index.php/php/article/view/956
Abdelfattah MG, Hussein MT, Ragab SMM, Abou Khalil NS, and Attaai AH. The effects of ginger (Zingiber officinale) roots on the reproductive aspects in male Japanese quails (Coturnix japonica). BMC Vet Res. 2023; 19(1): 34. DOI: 10.1186/s12917-023-03576-6
Abdul-Majeed A, and Al-Krad H. Influence of ginger as an antioxidant on the physiological performance of male quail stressed by hydrogen peroxide. Mesopotamia J Agric. 2023; 51(1): 141-151. DOI: 10.33899/magri.2023.139269.1224
Iheanacho GC, Ajayi EA, Sholademi EL, Abu OA, Akindoyin MO, Abolude AT, et al. Haematology and serum biochemistry of broiler chickens on dietary supplementation of garlic and ginger powder. Am J Agric Sci Eng Technol. 2024; 8(3): 1-9. DOI: 10.54536/ajaset.v8i3.3335
Li Z, Qumar M, Irfan M, Khan M, Faran G, Abbas G, et al. Impact of dietary turmeric and ginger powder on performance, serum chemistry and gut microbiota in laying hens. J Appl Poult Res. 2025; 34(4): 100605. DOI: 10.1016/j.japr.2025.100605
Shahrajabian MH, Sun W, and Cheng Q. Clinical aspects and health benefits of ginger (Zingiber officinale) in both traditional Chinese medicine and modern industry. Acta Agric Scand S B Soil Plant Sci. 2019; 69(6): 546-556. DOI: 10.1080/09064710.2019.1606930
Mao QQ, Xu XY, Cao SY, Gan RY, Corke H, Beta T, et al. Bioactive compounds and bioactivities of ginger (Zingiber officinale Roscoe). Foods. 2019; 8(6): 185. DOI: 10.3390/foods8060185
Umoru JIA, and Agbaye FP. Performance, serum biochemical and haematological response of broiler chickens fed mixture of ginger (Zingiber officinale) and garlic (Allium sativum) in diets. Eur J Appl Sci. 2022; 10(2): 596-601. DOI: 10.14738/aivp.102.12216
Gaikwad DS, and Fulpagare YG. Effect of dietary supplementation of ginger and cinnamon on blood profile of broilers. Int J Livest Res. 2020; 10(7): 162-166. DOI: 10.5455/ijlr.20200306072321
Malekizadeh M, Moeini MM, and Ghazi S. The effects of different levels of ginger (Zingiber officinale Roscoe) and turmeric (Curcuma longa Linn) rhizomes powder on some blood metabolites and Production performance characteristics of laying hens. J Agr Sci Tech. 2012; 14: 127-134. DOI:
Sharma Y. Ginger (Zingiber officinale) an elixir of life: A review. Pharma Innov J. 2017; 6(10): 22-27. Available at: https://www.thepharmajournal.com/archives/
Herve T, Raphaël KJ, Ferdinand N, Victor Herman N, Willy Marvel NM, Cyril D'Alex T, et al. Effects of ginger (Zingiber officinale, Roscoe) essential oil on growth and laying performances, serum metabolites, and egg yolk antioxidant and cholesterol status in laying Japanese quail. J Vet Med. 2019; 2019(1): 7857504. DOI: 10.1155/2019/7857504
Wen C, Liu Y, Ye Y, Tao Z, Cheng T, and Zhou Y. Effects of gingerols-rich extract of ginger on growth performance, serum metabolites, meat activity of heat-stressed broilers. J Therm Biol. 2020; 89: 102544. DOI: 10.1016/j.jtherbio.2020.102544
Yavas I, Adabi SG, and Ceylan N. Liver haemorrhagic syndrome in broilers: its effect on serum parameters, antioxidant capacity, liver enzymes and fatty acid profile of liver. Vet Med Sci. 2025; 11(3): e70372. DOI: 10.1002/vms3.70372
McGill MR. The past and present of serum aminotransferases and the future of liver injury biomarkers. EXCLI J. 2016; 15: 817-828. DOI: 10.17179/excli2016-800
Shang HM, Zhao JC, Dong XQ, and Guo Y. Inulin improves the egg production performance and affects the cecum microbiota of laying hens. Int J Biol Macromol. 2020; 155: 1599-1609. DOI: 10.1016/j.ijbiomac.2019.11.137
Joshi D, Srivastav SK, Belemkar S, and Dixit VA. Zingiber officinale and 6-gingerol alleviate liver and kidney dysfunctions and oxidative stress induced by mercuric chloride in male rats: A protective approach. Biomed Pharmacother. 2017; 91: 645-655. DOI: 10.1016/j.biopha.2017.04.108