_1711987278 20240401160118000 Rovedar Daryoushbabazadeh@gmail.com Rovedar Journal of World’s Poultry Science J. World's Poult. Sci. 2980-7999 03 25 2024 3 1 Timothy Kuka https://orcid.org/0000-0002-6482-4821 Oluwafunmilayo Adeleye https://orcid.org/0000-0001-6804-6038 Abideen Adetona https://orcid.org/0000-0002-9207-1214 Introduction: Inefficient poultry production has been a serious challenge due to poor performance and scarcity of feed resources, which necessitate the exploration of alternatives. This study was conducted to assess the effect of Saccharomyces cerevisiae (SC) as a supplemental protein and growth promoter in different cereal-based diets on growth performance, serum biochemistry, characteristics of digesta, and nutrient digestibility of broiler chickens. Materials and methods: A total of 324 day-old broiler chickens, comprising of mix sexes with an average weight of 45.36 ± 0.73, were randomly assigned to nine treatments, each consisting of three replicates with 12 birds per replicate. Three diets were formulated, each incorporating maize, sorghum, and wheat. The diets varied in the SC inclusion at levels of 0%, 5%, and 0.2% oxytetracycline (used as a growth promoter). The inclusion of oxytetracycline was to simulate the practice of in-feed antibiotics growth promoter, whereas yeast served as supplemental protein and growth promoter. Titanium dioxide was included in the feed at 0.2% on day 21 of the experiment to help estimate nutrient digestibility.   Results: Weight gain and feed conversion ratio were significantly lower in the groups fed sorghum with and without yeast. The groups fed maize with SC and oxytetracycline had the lowest blood glucose. Maize and sorghum without SC had the highest pH values. Protein digestibility was the lowest in the group fed sorghum with SC and wheat without SC. Conclusion: Individual cereal diets performed competitively, supplementation of SC in different cereal-based diets did not influence their contribution and performance of the chickens. The inclusion of 5% SC reduced protein digestibility. Oxytetracycline yeast as a supplemental protein and growth promoter did not improve the performance of the chicks. 03 25 2024 12 18 https://creativecommons.org/licenses/by/4.0 10.58803/jwps.v3i1.23 https://jwps.rovedar.com/index.php/JWPS/article/view/23 https://jwps.rovedar.com/index.php/JWPS/article/download/23/51 https://jwps.rovedar.com/index.php/JWPS/article/download/23/51 Thirumalaisamy G, Muralidharan J, Senthilkumar S, Sayee RH and Priyadharsini M. Cost-effective feeding of poultry. Int J Sci Environ & Technol. 2016; 5(6): 3997-4005. Available at: www.ijset.net 10.2298/BAH0906387P 10.22358/jafs/66297/2010 10.1016/j.tvjl.2010.03.003 10.1128/iai.64.12.5225-5232.1996 10.1016/S1286-4579(02)01592-7 10.1093/ps/84.7.1015 10.5713/ajas.2011.10334 10.1128/IAI.69.4.2762-2765.2001 10.1093/ps/80.6.718 Shahryar HA, Ahmadzadeh A, and Lotfi A. Possibilities of inclusion of Saccharomyces cerevisiae as replacement for fish meal or poultry meat by-product in broiler chicken diet. J Biol Environ Sci. 2012; 6(18): 249-251. Available at: https://dergipark.org.tr/en/download/article-file/497497 Adebiyi OA, Makanjuola BA, Bankole TO, and Adeyori AS. Yeast culture (Saccharomyces cerevisiae) supplementation: Effect on the performance and gut morphology of broiler birds. Glob J Sci Front Res. 2012; 12(6): 1-7. Available at: https://globaljournals.org/GJSFR_Volume12/5-Yeast-Culture-Saccharomyces-Cerevis.pdf 10.1079/BJN/2002552 10.1093/japr/14.4.750 10.3923/ajft.2011.103.116 Yalçinkaya İT, Güngör T, Başalan M, and Erdem E. Mannan oligosaccharides (MOS) from Saccharomyces cerevisiae in broilers: Effects on performance and blood biochemistry. Turk J Vet Anim Sci. 2008; 32(1): 43-48. Available at: https://journals.tubitak.gov.tr/veterinary/vol32/iss1/8 National research council (NRC). Nutrient requirements of poultry. 9th revised ed. Washington D.C: National Academy Press; 1994. Available at: https://vetbooks.ir/nutrient-requirements-of-poultry-9th-revised-edition 10.3382/ps/pev116 10.22358/jafs/67925/2002 10.1016/0377-8401(95)00916-7 Adejumo DO, Onitade AA, Olutunde TO, and Babatunde, GM. The effect of concentration, age and duration of feeding supplemented yeast (Levucel SB) in a higher fibre diet on the performance of broiler chickens. J Sus Trop Agric Res. 2005; 13: 58-65. Ahiwe EU, Emenalom OO, Etu, EB, Okehie UN, Odoemelam VU, Uchegbu MC and Okenyi C. Effect of Broiler Starter Diet Containing Royal Yeast Additive on Broiler Starter Performance and Economic of Production. Int J Agric & Rural Dev. 2015; 18(1): 2024-2028. Available at: https://www.ijard.com/vol%2018%20No1%202015.html 10.1046/j.1472-765x.2000.00746.x 10.1093/japr/16.2.280 10.3923/ijps.2004.179.188 10.1080/00071660601050755 10.1093/ps/76.9.1227 Shareef AM, and Al-Dabbagh AS. Effect of probiotic (Saccharomyces cerevisiae) on performance of broiler chicks. Iraqi J Vet Sci. 2009; 23(1): 23-29. Available at: https://citeseerx.ist.psu.edu/document? repid=rep1&type=pdf&doi=285861c6269dd71656aa4c6fee424044fb45e23a 10.3923/ajpsaj.2008.53.57 10.3382/ps.2010-00832 10.1080/00071669408417719 10.1017/S0007114500001574 10.1016/j.anifeedsci.2017.09.012